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Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer.
Hasani-Sadrabadi, Mohammad Mahdi; Taranejoo, Shahrouz; Dashtimoghadam, Erfan; Bahlakeh, Ghasem; Majedi, Fatemeh Sadat; VanDersarl, Jules John; Janmaleki, Mohsen; Sharifi, Fatemeh; Bertsch, Arnaud; Hourigan, Kerry; Tayebi, Lobat; Renaud, Philippe; Jacob, Karl I.
Affiliation
  • Hasani-Sadrabadi MM; Parker H. Petit Institute for Bioengineering and Bioscience, G. W. Woodruff School of Mechanical Engineering and School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0295, USA.
  • Taranejoo S; Department of Chemical Engineering, Monash University, Melbourne, VIC, 3168, Australia.
  • Dashtimoghadam E; Laboratory for Biomedical Engineering/Fluids, Laboratory for Aeronautical and Industrial Research, Department of Mechanical and Aerospace Engineering, Faculty of Engineering, Monash University, Melbourne, VIC, 3168, Australia.
  • Bahlakeh G; Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, WI, 53201, USA.
  • Majedi FS; Department of Chemical Engineering, Amirkabir University of Technology, Tehran, 49417-15344, Iran.
  • VanDersarl JJ; Department of Bioengineering, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
  • Janmaleki M; Laboratoire de Microsystemes (LMIS4), Institute of Microengineering and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
  • Sharifi F; Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 19857-17444, Iran.
  • Bertsch A; Department of Mechanical Engineering, Sharif University of Technology, Tehran, 11365-11155, Iran.
  • Hourigan K; Laboratoire de Microsystemes (LMIS4), Institute of Microengineering and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
  • Tayebi L; Department of Chemical Engineering, Monash University, Melbourne, VIC, 3168, Australia.
  • Renaud P; Laboratory for Biomedical Engineering/Fluids, Laboratory for Aeronautical and Industrial Research, Department of Mechanical and Aerospace Engineering, Faculty of Engineering, Monash University, Melbourne, VIC, 3168, Australia.
  • Jacob KI; Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, WI, 53201, USA.
Adv Mater ; 28(21): 4134-41, 2016 Jun.
Article in En | MEDLINE | ID: mdl-27001745
A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microfluidics Limits: Humans Language: En Journal: Adv Mater Journal subject: BIOFISICA / QUIMICA Year: 2016 Document type: Article Affiliation country: United States Country of publication: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microfluidics Limits: Humans Language: En Journal: Adv Mater Journal subject: BIOFISICA / QUIMICA Year: 2016 Document type: Article Affiliation country: United States Country of publication: Germany