CYP21A2 expression is localized in the developing distal epithelium of the human perinatal lung and is compatible with in situ production and intracrine actions of active glucocorticoids.

Bouhaddioui, Wafae; Provost, Pierre R; Tremblay, Yves

Bouhaddioui, Wafae; Provost, Pierre R; Tremblay, Yves.

Affiliation

Bouhaddioui W; Reproduction, Mother and Youth Health, Centre de recherche CHU de Québec, Québec, QC, Canada; Centre de Recherche en Biologie de la Reproduction (CRBR), Faculté de Médecine, Université Laval, Québec, QC, Canada.
Provost PR; Reproduction, Mother and Youth Health, Centre de recherche CHU de Québec, Québec, QC, Canada; Department of Obstetrics/Gynecology & Reproduction, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de Recherche en Biologie de la Reproduction (CRBR), Faculté de Médecine, Université Laval, Québec, QC, Canada.
Tremblay Y; Reproduction, Mother and Youth Health, Centre de recherche CHU de Québec, Québec, QC, Canada; Department of Obstetrics/Gynecology & Reproduction, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de Recherche en Biologie de la Reproduction (CRBR), Faculté de Médecine, Université Laval, Québec, QC, Canada. Electronic address: yves.tremblay@crchudequebec.ulaval.ca.

J Steroid Biochem Mol Biol ; 163: 12-9, 2016 10.

Article in En | MEDLINE | ID: mdl-27004467

Subject(s)

Gene Expression Regulation, Developmental; Lung/metabolism; RNA, Messenger/genetics; Respiratory Mucosa/metabolism; Steroid 17-alpha-Hydroxylase/genetics; Steroid 21-Hydroxylase/genetics; Age Factors; Aldosterone/metabolism; Cytochrome P-450 CYP11B2/genetics; Cytochrome P-450 CYP11B2/metabolism; Desoxycorticosterone/metabolism; Female; Fetus; Gestational Age; Humans; Hydrocortisone/metabolism; Lung/growth & development; Male; Pregnancy; RNA, Messenger/metabolism; Respiratory Mucosa/growth & development; Sex Factors; Steroid 11-beta-Hydroxylase/genetics; Steroid 11-beta-Hydroxylase/metabolism; Steroid 17-alpha-Hydroxylase/metabolism; Steroid 21-Hydroxylase/metabolism

Key words

11-Deoxycortisol; 21-Hydroxylase; Deoxycorticosterone; Glucocorticoids; Lung development; Mineralocorticoids; Respiratory distress syndrome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Steroid 17-alpha-Hydroxylase / Steroid 21-Hydroxylase / Gene Expression Regulation, Developmental / Respiratory Mucosa / Lung Type of study: Prognostic_studies Limits: Female / Humans / Male / Pregnancy Language: En Journal: J Steroid Biochem Mol Biol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2016 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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