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TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors.
Amin, Amit Dipak; Li, Lingxiao; Rajan, Soumya S; Gokhale, Vijay; Groysman, Matthew J; Pongtornpipat, Praechompoo; Tapia, Edgar O; Wang, Mengdie; Schatz, Jonathan H.
Affiliation
  • Amin AD; Department of Medicine, Division of Hematology-Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Li L; Department of Medicine, Division of Hematology-Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Rajan SS; Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Gokhale V; BIO5 Institute, University of Arizona, Tucson, AZ, USA.
  • Groysman MJ; Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA.
  • Pongtornpipat P; Undergraduate Biology Research Program, University of Arizona, Tucson, AZ, USA.
  • Tapia EO; BIO5 Institute, University of Arizona, Tucson, AZ, USA.
  • Wang M; Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, USA.
  • Schatz JH; Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, USA.
Oncotarget ; 7(17): 23715-29, 2016 Apr 26.
Article in En | MEDLINE | ID: mdl-27009859
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Oncogene Proteins, Fusion / Receptor Protein-Tyrosine Kinases / Carcinoma, Non-Small-Cell Lung / Drug Resistance, Neoplasm / Protein Kinase Inhibitors / Lung Neoplasms / Mutation Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Oncotarget Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Oncogene Proteins, Fusion / Receptor Protein-Tyrosine Kinases / Carcinoma, Non-Small-Cell Lung / Drug Resistance, Neoplasm / Protein Kinase Inhibitors / Lung Neoplasms / Mutation Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Oncotarget Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States