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Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.
Voigt, Franka; Wiedemann, Lisa; Zuliani, Cecilia; Querques, Irma; Sebe, Attila; Mátés, Lajos; Izsvák, Zsuzsanna; Ivics, Zoltán; Barabas, Orsolya.
Affiliation
  • Voigt F; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.
  • Wiedemann L; Paul Ehrlich Institute, Division of Medical Biotechnology, Paul Ehrlich Strasse 51-59, Langen 63225, Germany.
  • Zuliani C; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.
  • Querques I; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.
  • Sebe A; Paul Ehrlich Institute, Division of Medical Biotechnology, Paul Ehrlich Strasse 51-59, Langen 63225, Germany.
  • Mátés L; Max Delbrück Center for Molecular Medicine, Robert Rössle Strasse 10, Berlin 13092, Germany.
  • Izsvák Z; Max Delbrück Center for Molecular Medicine, Robert Rössle Strasse 10, Berlin 13092, Germany.
  • Ivics Z; Paul Ehrlich Institute, Division of Medical Biotechnology, Paul Ehrlich Strasse 51-59, Langen 63225, Germany.
  • Barabas O; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.
Nat Commun ; 7: 11126, 2016 Mar 30.
Article in En | MEDLINE | ID: mdl-27025571
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Engineering / Transposases / Mutation Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2016 Document type: Article Affiliation country: Germany Country of publication: United kingdom
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Engineering / Transposases / Mutation Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2016 Document type: Article Affiliation country: Germany Country of publication: United kingdom