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Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery.
Yang, Peng-Yu; Zou, Huafei; Chao, Elizabeth; Sherwood, Lance; Nunez, Vanessa; Keeney, Michael; Ghartey-Tagoe, Esi; Ding, Zhongli; Quirino, Herlinda; Luo, Xiaozhou; Welzel, Gus; Chen, Guohua; Singh, Parminder; Woods, Ashley K; Schultz, Peter G; Shen, Weijun.
Affiliation
  • Yang PY; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037; California Institute for Biomedical Research, La Jolla, CA 92037;
  • Zou H; California Institute for Biomedical Research, La Jolla, CA 92037;
  • Chao E; California Institute for Biomedical Research, La Jolla, CA 92037;
  • Sherwood L; California Institute for Biomedical Research, La Jolla, CA 92037;
  • Nunez V; California Institute for Biomedical Research, La Jolla, CA 92037;
  • Keeney M; Corium International, Inc., Menlo Park, CA 94025.
  • Ghartey-Tagoe E; Corium International, Inc., Menlo Park, CA 94025.
  • Ding Z; Corium International, Inc., Menlo Park, CA 94025.
  • Quirino H; California Institute for Biomedical Research, La Jolla, CA 92037;
  • Luo X; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037;
  • Welzel G; California Institute for Biomedical Research, La Jolla, CA 92037;
  • Chen G; Corium International, Inc., Menlo Park, CA 94025.
  • Singh P; Corium International, Inc., Menlo Park, CA 94025.
  • Woods AK; California Institute for Biomedical Research, La Jolla, CA 92037; awoods@calibr.org schultz@scripps.edu wshen@calibr.org.
  • Schultz PG; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037; California Institute for Biomedical Research, La Jolla, CA 92037; awoods@calibr.org schultz@scripps.edu wshen@calibr.org.
  • Shen W; California Institute for Biomedical Research, La Jolla, CA 92037; awoods@calibr.org schultz@scripps.edu wshen@calibr.org.
Proc Natl Acad Sci U S A ; 113(15): 4140-5, 2016 Apr 12.
Article in En | MEDLINE | ID: mdl-27035989
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Engineering / Glucagon-Like Peptide 1 Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Engineering / Glucagon-Like Peptide 1 Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article Country of publication: United States