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Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression.
Morales, Cyndi R; Li, Dan L; Pedrozo, Zully; May, Herman I; Jiang, Nan; Kyrychenko, Viktoriia; Cho, Geoffrey W; Kim, Soo Young; Wang, Zhao V; Rotter, David; Rothermel, Beverly A; Schneider, Jay W; Lavandero, Sergio; Gillette, Thomas G; Hill, Joseph A.
Affiliation
  • Morales CR; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.
  • Li DL; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.
  • Pedrozo Z; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA. Advanced Center for Chronic Diseases, Facultad Ciencias Químicas y Farmacéuticas & Facultad Medicina, Universidad de Chile, Santiago 8380492, Chile.
  • May HI; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.
  • Jiang N; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.
  • Kyrychenko V; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.
  • Cho GW; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.
  • Kim SY; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.
  • Wang ZV; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.
  • Rotter D; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.
  • Rothermel BA; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.
  • Schneider JW; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.
  • Lavandero S; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA. Advanced Center for Chronic Diseases, Facultad Ciencias Químicas y Farmacéuticas & Facultad Medicina, Universidad de Chile, Santiago 8380492, Chile.
  • Gillette TG; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.
  • Hill JA; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA. joseph.hill@utsouthwestern.edu.
Sci Signal ; 9(422): ra34, 2016 Apr 05.
Article in En | MEDLINE | ID: mdl-27048565
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiomegaly / Tumor Suppressor Proteins / Histone Deacetylase 1 / Histone Deacetylase 2 / TOR Serine-Threonine Kinases Limits: Animals / Humans / Male Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiomegaly / Tumor Suppressor Proteins / Histone Deacetylase 1 / Histone Deacetylase 2 / TOR Serine-Threonine Kinases Limits: Animals / Humans / Male Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States