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An unusual sesquiterpene coumarin from the seeds of Ferula sinkiangensis.
Li, Guang-Zhi; Wang, Jun-Chi; Li, Xiao-Jin; Cao, Li; Gao, Li; Lv, Na; Si, Jian-Yong.
Affiliation
  • Li GZ; a Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing 100193 , China.
  • Wang JC; a Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing 100193 , China.
  • Li XJ; b Xinjiang Institute of Chinese Materia Medica and Ethical Materia Medica , Urumqi 830002 , China.
  • Cao L; a Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing 100193 , China.
  • Gao L; a Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing 100193 , China.
  • Lv N; a Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing 100193 , China.
  • Si JY; a Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing 100193 , China.
J Asian Nat Prod Res ; 18(9): 891-6, 2016 Sep.
Article in En | MEDLINE | ID: mdl-27053285
A sesquiterpene coumarin, sinkiangenorin E, consisting of a novel bicyclo[4.3.1]decane-type sesquiterpene system, was isolated from the seeds of Ferula sinkiangensis. The structure of sinkiangenorin E including the relative stereochemistry and the absolute configuration was elucidated on the basis of spectroscopic data. The new compound showed cytotoxic activity against AGS cells (IC50, 12.7 µM) and inhibiting effect against influenza A H1N1 (IC50, 4.0 µM), which provided important clues for the study on the bioactivities of this type of sesquiterpene coumarins.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Drugs, Chinese Herbal / Coumarins / Ferula Limits: Humans Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2016 Document type: Article Affiliation country: China Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Drugs, Chinese Herbal / Coumarins / Ferula Limits: Humans Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2016 Document type: Article Affiliation country: China Country of publication: United kingdom