S-protected thiolated hydroxyethyl cellulose (HEC): Novel mucoadhesive excipient with improved stability.

Leonaviciute, Gintare; Bonengel, Sonja; Mahmood, Arshad; Ahmad Idrees, Muneeb; Bernkop-Schnürch, Andreas

Leonaviciute, Gintare; Bonengel, Sonja; Mahmood, Arshad; Ahmad Idrees, Muneeb; Bernkop-Schnürch, Andreas.

Affiliation

Leonaviciute G; Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Bonengel S; Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Mahmood A; Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Ahmad Idrees M; Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Bernkop-Schnürch A; Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria. Electronic address: andreas.bernkop@uibk.ac.at.

Carbohydr Polym ; 144: 514-21, 2016 Jun 25.

Article in En | MEDLINE | ID: mdl-27083843

Subject(s)

Cellulose/analogs & derivatives; Excipients/chemistry; Sulfhydryl Compounds/chemistry; Adhesiveness; Animals; Caco-2 Cells; Cellulose/chemistry; Cellulose/metabolism; Cellulose/toxicity; Cysteamine/chemistry; Drug Stability; Excipients/metabolism; Excipients/toxicity; Glycoside Hydrolases/metabolism; Humans; Intestinal Mucosa/chemistry; Muramidase/metabolism; Niacinamide/chemistry; Rheology; Swine

Key words

5,5'-Dithiobis(2-nitro-benzoic acid) (Ellman's reagent) (PubChem CID: 62549); Cellulase from Aspergillus niger (PubChem CID: 58863022); Cysteamine (PubChem CID: 6058); Enzymatic degradation; Glutathione (PubChem CID: 7048684); Hydroxyethyl cellulose; Mucoadhesion; Sodium cyanoborohydride (PubChem CID: 20587905); Sodium periodate (PubChem CID: 23667635); Thiolation; Thiomer; Trinitrobenzenesulfonic acid (PubChem CID: 11045)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfhydryl Compounds / Cellulose / Excipients Limits: Animals / Humans Language: En Journal: Carbohydr Polym Year: 2016 Document type: Article Affiliation country: Austria Country of publication: United kingdom

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