SMOC Binds to Pro-EGF, but Does Not Induce Erk Phosphorylation via the EGFR.

Thomas, J Terrig; Chhuy-Hy, Lina; Andrykovich, Kristin R; Moos, Malcolm

Thomas, J Terrig; Chhuy-Hy, Lina; Andrykovich, Kristin R; Moos, Malcolm.

Affiliation

Thomas JT; FDA/Center for Biologics Evaluation and Research, Division of Cellular and Gene Therapies Office of Cellular, Tissue, and Gene Therapies, Silver Spring, MD, United States of America.
Chhuy-Hy L; FDA/Center for Biologics Evaluation and Research, Division of Cellular and Gene Therapies Office of Cellular, Tissue, and Gene Therapies, Silver Spring, MD, United States of America.
Andrykovich KR; FDA/Center for Biologics Evaluation and Research, Division of Cellular and Gene Therapies Office of Cellular, Tissue, and Gene Therapies, Silver Spring, MD, United States of America.
Moos M; FDA/Center for Biologics Evaluation and Research, Division of Cellular and Gene Therapies Office of Cellular, Tissue, and Gene Therapies, Silver Spring, MD, United States of America.

PLoS One ; 11(4): e0154294, 2016.

Article in En | MEDLINE | ID: mdl-27101391

Subject(s)

Epidermal Growth Factor/metabolism; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Osteonectin/metabolism; Protein Precursors/metabolism; Xenopus Proteins/metabolism; Xenopus laevis/metabolism; Amino Acid Sequence; Animals; Binding Sites; Calcium-Binding Proteins/genetics; Calcium-Binding Proteins/metabolism; Embryo, Nonmammalian; Epidermal Growth Factor/genetics; ErbB Receptors/genetics; ErbB Receptors/metabolism; Escherichia coli/genetics; Escherichia coli/metabolism; Gene Expression Regulation; HEK293 Cells; Humans; Mitogen-Activated Protein Kinase 1/genetics; Mitogen-Activated Protein Kinase 3/genetics; Osteonectin/genetics; Phosphorylation; Protein Binding; Protein Interaction Domains and Motifs; Protein Precursors/genetics; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Signal Transduction; Species Specificity; Xenopus Proteins/genetics; Xenopus laevis/embryology; Xenopus laevis/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Precursors / Xenopus laevis / Osteonectin / Mitogen-Activated Protein Kinase 1 / Xenopus Proteins / Mitogen-Activated Protein Kinase 3 / Epidermal Growth Factor Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2016 Document type: Article Affiliation country: United States

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