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Impact on abiraterone pharmacokinetics and safety: Open-label drug-drug interaction studies with ketoconazole and rifampicin.
Bernard, Apexa; Vaccaro, Nicole; Acharya, Milin; Jiao, James; Monbaliu, Johan; De Vries, Ronald; Stieltjes, Hans; Yu, Margaret; Tran, Namphuong; Chien, Caly.
Affiliation
  • Bernard A; Janssen Research & Development, Clinical Pharmacology, Raritan, NJ, USA.
  • Vaccaro N; Janssen Research & Development, Clinical Pharmacology, San Diego, CA, USA.
  • Acharya M; Janssen Research & Development, Clinical Pharmacology, Raritan, NJ, USA.
  • Jiao J; Janssen Research & Development, Biometrics and Reporting, Raritan, NJ, USA.
  • Monbaliu J; Janssen Research & Development, Preclinical Project Development, Beerse, Belgium.
  • De Vries R; Janssen Research & Development, Bioanalysis, Beerse, Belgium.
  • Stieltjes H; Janssen Research & Development, Bioanalysis, Beerse, Belgium.
  • Yu M; Janssen Research & Development, WC Clinical Oncology, Los Angeles, CA, USA.
  • Tran N; Janssen Research & Development, WC Clinical Oncology, Los Angeles, CA, USA.
  • Chien C; Janssen Research & Development, Clinical Pharmacology, Titusville, NJ, USA.
Clin Pharmacol Drug Dev ; 4(1): 63-73, 2015 01.
Article in En | MEDLINE | ID: mdl-27128004
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / Cytochrome P-450 CYP3A / Cytochrome P-450 CYP3A Inducers / Cytochrome P-450 CYP3A Inhibitors / Abiraterone Acetate / Ketoconazole Type of study: Prognostic_studies Limits: Adolescent / Adult / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Clin Pharmacol Drug Dev Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / Cytochrome P-450 CYP3A / Cytochrome P-450 CYP3A Inducers / Cytochrome P-450 CYP3A Inhibitors / Abiraterone Acetate / Ketoconazole Type of study: Prognostic_studies Limits: Adolescent / Adult / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Clin Pharmacol Drug Dev Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States