There and back again: coordinated transcription, translation and transport in axonal survival and regeneration.
Curr Opin Neurobiol
; 39: 62-8, 2016 08.
Article
in En
| MEDLINE
| ID: mdl-27131422
ABSTRACT
Neurons are highly polarized cells with axonal and dendritic projections that extend over long distances. Target-derived neurotrophins provide local axonal cues that function in developing neurons, while physical or chemical injuries to long axons initiate local environmental cues in mature neurons. In both instances initial responses at the location of stimulation or injury must be coordinated with changes in the transcriptional program and subsequent changes in axonal protein content. To achieve this coordination, intracellular signals move 'there and back again' between axons and the nucleus. Here, we review new findings on neuronal responses to growth factors and injury and highlight the coordination of transcription, translation and transport required to mediate communication between axons and cell bodies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Axons
/
Axonal Transport
/
Nerve Regeneration
Language:
En
Journal:
Curr Opin Neurobiol
Journal subject:
BIOLOGIA
/
NEUROLOGIA
Year:
2016
Document type:
Article
Affiliation country:
United States