Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz.

Dalwadi, Dhwanil A; Kim, Seongcheol; Amdani, Shahnawaz M; Chen, Zhenglan; Huang, Ren-Qi; Schetz, John A

Dalwadi, Dhwanil A; Kim, Seongcheol; Amdani, Shahnawaz M; Chen, Zhenglan; Huang, Ren-Qi; Schetz, John A.

Affiliation

Dalwadi DA; Department of Pharmacology & Neuroscience, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States.
Kim S; Department of Pharmacology & Neuroscience, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States.
Amdani SM; Department of Pharmacology & Neuroscience, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States.
Chen Z; Department of Pharmacology & Neuroscience, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States.
Huang RQ; Department of Pharmacology & Neuroscience, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States; Institute for Healthy Aging, Center for Neuroscience Discovery, University of North Texas Health Science
Schetz JA; Department of Pharmacology & Neuroscience, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States; Institute for Healthy Aging, Center for Neuroscience Discovery, University of North Texas Health Science

Pharmacol Res ; 110: 10-24, 2016 08.

Article in En | MEDLINE | ID: mdl-27157251

Subject(s)

Anti-HIV Agents/toxicity; Benzoxazines/toxicity; Brain/drug effects; HIV Infections/drug therapy; HIV-1/drug effects; Receptors, Serotonin/drug effects; Reverse Transcriptase Inhibitors/toxicity; Serotonin Antagonists/toxicity; Alkynes; Animals; Anti-HIV Agents/metabolism; Benzoxazines/metabolism; Binding, Competitive; Brain/metabolism; CHO Cells; Calcium Signaling/drug effects; Cricetulus; Cyclopropanes; Dose-Response Relationship, Drug; Drug Partial Agonism; Guinea Pigs; HEK293 Cells; HIV Infections/diagnosis; HIV Infections/virology; HIV-1/pathogenicity; HeLa Cells; Humans; Membrane Potentials; Monoamine Oxidase Inhibitors/toxicity; Protein Binding; Radioligand Assay; Receptors, Muscarinic/drug effects; Receptors, Muscarinic/genetics; Receptors, Muscarinic/metabolism; Receptors, Serotonin/genetics; Receptors, Serotonin/metabolism; Reverse Transcriptase Inhibitors/metabolism; Time Factors; Transfection

Key words

5-HT(2A); 5-HT(2C); 5-HT(6); Atropine (PubChem CID174174); DOI; DOI (PubChem CID170617); Efavirenz; Efavirenz (PubChem CID64139); Emtricitabine (PubChem CID60877); LSD; LSD Tartrate (PubChem CID159828); Nevirapine (PubChem CID4463); Scopolamine (PubChem CID3000322); Serotonin 5-Hydroxytryptamine (PubChem CID5202); TCB-2 (PubChem CID71433791); Zidovudine (PubChem CID35370); α-Methyl-5HT (PubChem CID2107)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serotonin Antagonists / Brain / HIV Infections / HIV-1 / Receptors, Serotonin / Reverse Transcriptase Inhibitors / Anti-HIV Agents / Benzoxazines Type of study: Diagnostic_studies / Guideline Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2016 Document type: Article Affiliation country: United States Country of publication: Netherlands

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