Palladium-Catalyzed Directed para C-H Functionalization of Phenols.
Angew Chem Int Ed Engl
; 55(27): 7751-5, 2016 06 27.
Article
in En
| MEDLINE
| ID: mdl-27159887
ABSTRACT
Various practical methods for the selective C-H functionalization of the ortho and recently also of the meta position of an arene have already been developed. Following our recent development of the directing-group-assisted para C-H functionalization of toluene derivatives, we herein report the first remote para C-H functionalization of phenol derivatives by using a recyclable silicon-containing biphenyl-based template. The effectiveness of this strategy was illustrated with different synthetic elaborations and by the synthesis of various phenol-based natural products.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2016
Document type:
Article
Affiliation country:
India