Correlation between liver cirrhosis and risk of death from oral cancer: Taiwan cohort study.
J Laryngol Otol
; 130(6): 565-70, 2016 Jun.
Article
in En
| MEDLINE
| ID: mdl-27160281
ABSTRACT
BACKGROUND:
A nationwide population-based cohort was used to examine the severity of liver cirrhosis and risk of mortality from oral cancer.METHODS:
The cohort consisted of 3583 patients with oral cancer treated by surgery between 2008 and 2011 in Taiwan. They were grouped on the basis of normal liver function (n = 3471), cirrhosis without decompensation (n = 72) and cirrhosis with decompensation (n = 40). The primary endpoint was mortality. Hazard ratios of death were also determined.RESULTS:
The mortality rates in the respective groups were 14.8 per cent, 20.8 per cent and 37.5 per cent at one year (p < 0.001). The adjusted hazard ratios of death at one year for each group compared to the normal group were 2.01 (p = 0.021) for cirrhotic patients without decompensation, 4.84 (p < 0.001) for those with decompensation and 2.65 (p < 0.001) for those receiving chemotherapy.CONCLUSION:
Liver cirrhosis can be used to predict one-year mortality in oral cancer patients. Chemotherapy should be used with caution and underlying co-morbidities should be managed in cirrhotic patients to reduce mortality risk.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mouth Neoplasms
/
Liver Cirrhosis
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
J Laryngol Otol
Journal subject:
OTORRINOLARINGOLOGIA
Year:
2016
Document type:
Article
Affiliation country:
Taiwan