Efficacy of the neurokinin-1 receptor antagonist rolapitant in preventing nausea and vomiting in patients receiving carboplatin-based chemotherapy.

Hesketh, Paul J; Schnadig, Ian D; Schwartzberg, Lee S; Modiano, Manuel R; Jordan, Karin; Arora, Sujata; Powers, Dan; Aapro, Matti

Hesketh, Paul J; Schnadig, Ian D; Schwartzberg, Lee S; Modiano, Manuel R; Jordan, Karin; Arora, Sujata; Powers, Dan; Aapro, Matti.

Affiliation

Hesketh PJ; Department of Hematology and Oncology, Lahey Hospital & Medical Center, Burlington, Massachusetts.
Schnadig ID; Compass Oncology, US Oncology Research, Tualatin, Oregon.
Schwartzberg LS; West Clinic, Memphis, Tennessee.
Modiano MR; Arizona Clinical Research Center and Arizona Oncology, Tucson, Arizona.
Jordan K; Hematology and Oncology, Department of Internal Medicine IV, Martin Luther University of Halle-Wittenberg, Halle, Germany.
Arora S; TESARO, Inc, Waltham, Massachusetts.
Powers D; TESARO, Inc, Waltham, Massachusetts.
Aapro M; Multidisciplinary Oncology Institute, Clinique de Genolier, Genolier, Switzerland.

Cancer ; 122(15): 2418-25, 2016 Aug 01.

Article in En | MEDLINE | ID: mdl-27176138

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/adverse effects; Nausea/drug therapy; Nausea/etiology; Neoplasms/complications; Neurokinin-1 Receptor Antagonists/therapeutic use; Spiro Compounds/therapeutic use; Vomiting/drug therapy; Vomiting/etiology; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Carboplatin/administration & dosage; Carboplatin/adverse effects; Chemoprevention; Female; Humans; Male; Middle Aged; Nausea/prevention & control; Neoplasms/drug therapy; Neoplasms/mortality; Neurokinin-1 Receptor Antagonists/adverse effects; Risk Factors; Spiro Compounds/adverse effects; Treatment Outcome; Vomiting/prevention & control

Key words

carboplatin; chemotherapy-induced nausea and vomiting; moderately emetogenic chemotherapy; neurokinin-1 receptor antagonist; rolapitant

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spiro Compounds / Vomiting / Antineoplastic Combined Chemotherapy Protocols / Neurokinin-1 Receptor Antagonists / Nausea / Neoplasms Type of study: Clinical_trials / Etiology_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Cancer Year: 2016 Document type: Article Country of publication: United States

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