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Disruption of the gene C12orf35 leads to increased productivities in recombinant CHO cell lines.
Ritter, Anett; Rauschert, Tatjana; Oertli, Mevion; Piehlmaier, Daniel; Mantas, Panagiotis; Kuntzelmann, Genevieve; Lageyre, Nadine; Brannetti, Barbara; Voedisch, Bernd; Geisse, Sabine; Jostock, Thomas; Laux, Holger.
Affiliation
  • Ritter A; Novartis Institutes for BioMedical Research, Basel, Switzerland. anett.ritter@novartis.com.
  • Rauschert T; Novartis Pharma AG, Integrated Biologics Profiling Unit, Werk Klybeck Postfach CH-4002, Basel, Switzerland. anett.ritter@novartis.com.
  • Oertli M; Novartis Pharma AG, Cell and Gene Therapies, Basel, Switzerland.
  • Piehlmaier D; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Mantas P; Novartis Pharma AG, Integrated Biologics Profiling Unit, Werk Klybeck Postfach CH-4002, Basel, Switzerland.
  • Kuntzelmann G; Novartis Pharma AG, Integrated Biologics Profiling Unit, Werk Klybeck Postfach CH-4002, Basel, Switzerland.
  • Lageyre N; Novartis Pharma AG, Integrated Biologics Profiling Unit, Werk Klybeck Postfach CH-4002, Basel, Switzerland.
  • Brannetti B; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Voedisch B; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Geisse S; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Jostock T; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Laux H; Novartis Institutes for BioMedical Research, Basel, Switzerland.
Biotechnol Bioeng ; 113(11): 2433-42, 2016 11.
Article in En | MEDLINE | ID: mdl-27183150
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Proteins / CHO Cells / Genetic Enhancement Limits: Animals Language: En Journal: Biotechnol Bioeng Year: 2016 Document type: Article Affiliation country: Switzerland Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Proteins / CHO Cells / Genetic Enhancement Limits: Animals Language: En Journal: Biotechnol Bioeng Year: 2016 Document type: Article Affiliation country: Switzerland Country of publication: United States