Oxidative stress and dysfunctional NRF2 underlie pachyonychia congenita phenotypes.

Kerns, Michelle L; Hakim, Jill M C; Lu, Rosemary G; Guo, Yajuan; Berroth, Andreas; Kaspar, Roger L; Coulombe, Pierre A

Kerns, Michelle L; Hakim, Jill M C; Lu, Rosemary G; Guo, Yajuan; Berroth, Andreas; Kaspar, Roger L; Coulombe, Pierre A.

J Clin Invest ; 126(6): 2356-66, 2016 06 01.

Article in En | MEDLINE | ID: mdl-27183391

Subject(s)

NF-E2-Related Factor 2/metabolism; Pachyonychia Congenita/metabolism; Animals; Disease Models, Animal; Glutathione/biosynthesis; Humans; Isothiocyanates/pharmacology; Keratin-16/genetics; Keratin-16/metabolism; Keratoderma, Palmoplantar/genetics; Keratoderma, Palmoplantar/metabolism; Keratoderma, Palmoplantar/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2/chemistry; NF-E2-Related Factor 2/deficiency; NF-E2-Related Factor 2/genetics; Oxidative Stress; Pachyonychia Congenita/genetics; Pachyonychia Congenita/pathology; Phenotype; Phosphorylation; RNA, Messenger/genetics; RNA, Messenger/metabolism; Sulfoxides

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NF-E2-Related Factor 2 / Pachyonychia Congenita Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Clin Invest Year: 2016 Document type: Article Country of publication: United States

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