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Systematic review with meta-analysis: the effect of tobacco smoking on the natural history of ulcerative colitis.
To, N; Ford, A C; Gracie, D J.
Affiliation
  • To N; Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.
  • Ford AC; Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK.
  • Gracie DJ; Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.
Aliment Pharmacol Ther ; 44(2): 117-26, 2016 07.
Article in En | MEDLINE | ID: mdl-27193202
BACKGROUND: Tobacco smoking is associated with a reduced risk of developing ulcerative colitis (UC). A high proportion of UC patients perceive a benefit in disease outcomes secondary to smoking. However, the effects of smoking on the natural history of UC are uncertain. AIM: To conduct a systematic review and meta-analysis of the effects of tobacco smoking on the natural history of UC. METHODS: A search of MEDLINE, EMBASE and EMBASE classic was carried out (up to December 2015) to identify observational studies reporting data on smoking and rates of colectomy, flare of disease activity, proximal disease extension, and development of pouchitis following panproctocolectomy and ileal pouch-anal anastomosis in patients with UC. Dichotomous data were pooled to obtain odds ratios (ORs), with 95% confidence intervals (CIs). RESULTS: The search identified 16 eligible studies: five (2615 patients) studying colectomy; four (620 patients) reporting on flare of disease activity; four (687 patients) examining proximal disease extension and three (355 patients) assessing development of pouchitis. Compared with nonsmokers, the odds of colectomy (OR = 0.89; 95% CI 0.62-1.26), flare of disease activity (OR = 1.26; 95% CI 0.65-2.44), proximal extension of disease (OR = 0.57; 95% CI 0.20-1.66) or the development of pouchitis (OR = 0.57; 95% CI 0.21-1.53) were not significantly lower in smokers. CONCLUSIONS: Smoking may not improve the natural history of ulcerative colitis. Given the health benefits of smoking cessation and the lack of clear benefit in ulcerative colitis, smoking cessation advice should be incorporated into guidance on the management of ulcerative colitis.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Smoking / Colitis, Ulcerative / Pouchitis Type of study: Observational_studies / Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Aliment Pharmacol Ther Journal subject: FARMACOLOGIA / GASTROENTEROLOGIA / TERAPIA POR MEDICAMENTOS Year: 2016 Document type: Article Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Smoking / Colitis, Ulcerative / Pouchitis Type of study: Observational_studies / Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Aliment Pharmacol Ther Journal subject: FARMACOLOGIA / GASTROENTEROLOGIA / TERAPIA POR MEDICAMENTOS Year: 2016 Document type: Article Country of publication: United kingdom