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Initial depression severity and response to antidepressants v. placebo: patient-level data analysis from 34 randomised controlled trials.
Rabinowitz, Jonathan; Werbeloff, Nomi; Mandel, Francine S; Menard, François; Marangell, Lauren; Kapur, Shitij.
Affiliation
  • Rabinowitz J; Jonathan Rabinowitz, PhD, Nomi Werbeloff, PhD, School of Social Work, Ramat Gan, Bar Ilan University, Israel; Francine S. Mandel, PhD, Pfizer Development Operations, New York, USA; François Menard, MD, Lundbec Research Department, Paris, France; Lauren Marangell, MD, Department of Psychiatry, Univer
  • Werbeloff N; Jonathan Rabinowitz, PhD, Nomi Werbeloff, PhD, School of Social Work, Ramat Gan, Bar Ilan University, Israel; Francine S. Mandel, PhD, Pfizer Development Operations, New York, USA; François Menard, MD, Lundbec Research Department, Paris, France; Lauren Marangell, MD, Department of Psychiatry, Univer
  • Mandel FS; Jonathan Rabinowitz, PhD, Nomi Werbeloff, PhD, School of Social Work, Ramat Gan, Bar Ilan University, Israel; Francine S. Mandel, PhD, Pfizer Development Operations, New York, USA; François Menard, MD, Lundbec Research Department, Paris, France; Lauren Marangell, MD, Department of Psychiatry, Univer
  • Menard F; Jonathan Rabinowitz, PhD, Nomi Werbeloff, PhD, School of Social Work, Ramat Gan, Bar Ilan University, Israel; Francine S. Mandel, PhD, Pfizer Development Operations, New York, USA; François Menard, MD, Lundbec Research Department, Paris, France; Lauren Marangell, MD, Department of Psychiatry, Univer
  • Marangell L; Jonathan Rabinowitz, PhD, Nomi Werbeloff, PhD, School of Social Work, Ramat Gan, Bar Ilan University, Israel; Francine S. Mandel, PhD, Pfizer Development Operations, New York, USA; François Menard, MD, Lundbec Research Department, Paris, France; Lauren Marangell, MD, Department of Psychiatry, Univer
  • Kapur S; Jonathan Rabinowitz, PhD, Nomi Werbeloff, PhD, School of Social Work, Ramat Gan, Bar Ilan University, Israel; Francine S. Mandel, PhD, Pfizer Development Operations, New York, USA; François Menard, MD, Lundbec Research Department, Paris, France; Lauren Marangell, MD, Department of Psychiatry, Univer
Br J Psychiatry ; 209(5): 427-428, 2016 11.
Article in En | MEDLINE | ID: mdl-27198482
ABSTRACT
Several often-cited meta-analyses have reported that the efficacy of antidepressant medications depends on the severity of depression. They found that drug-placebo differences increased as a function of initial severity, which was attributed to decreased responsiveness to placebo among patients with severe depression rather than to increased responsiveness to medication. We retested this using patient-level data and also undertaking a meta-analysis of trial-level data from 34 randomised placebo controlled trials (n = 10 737) from the NEWMEDS registry. Although our trial-level data support prevous findings, patient-level data did not show any significant effect of initial depression severity on drug v. placebo difference.
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Collection: 01-internacional Database: MEDLINE Main subject: Severity of Illness Index / Placebo Effect / Randomized Controlled Trials as Topic / Registries / Depressive Disorder, Major / Patient Outcome Assessment Type of study: Clinical_trials / Systematic_reviews Limits: Humans Language: En Journal: Br J Psychiatry Year: 2016 Document type: Article
Search on Google
Add to My VHL
Print
XML
PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Severity of Illness Index / Placebo Effect / Randomized Controlled Trials as Topic / Registries / Depressive Disorder, Major / Patient Outcome Assessment Type of study: Clinical_trials / Systematic_reviews Limits: Humans Language: En Journal: Br J Psychiatry Year: 2016 Document type: Article