Initial depression severity and response to antidepressants v. placebo: patient-level data analysis from 34 randomised controlled trials.
Br J Psychiatry
; 209(5): 427-428, 2016 11.
Article
in En
| MEDLINE
| ID: mdl-27198482
ABSTRACT
Several often-cited meta-analyses have reported that the efficacy of antidepressant medications depends on the severity of depression. They found that drug-placebo differences increased as a function of initial severity, which was attributed to decreased responsiveness to placebo among patients with severe depression rather than to increased responsiveness to medication. We retested this using patient-level data and also undertaking a meta-analysis of trial-level data from 34 randomised placebo controlled trials (n = 10 737) from the NEWMEDS registry. Although our trial-level data support prevous findings, patient-level data did not show any significant effect of initial depression severity on drug v. placebo difference.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Severity of Illness Index
/
Placebo Effect
/
Randomized Controlled Trials as Topic
/
Registries
/
Depressive Disorder, Major
/
Patient Outcome Assessment
Type of study:
Clinical_trials
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Br J Psychiatry
Year:
2016
Document type:
Article