Chronic vagal nerve stimulation prevents high-salt diet-induced endothelial dysfunction and aortic stiffening in stroke-prone spontaneously hypertensive rats.

Chapleau, Mark W; Rotella, Diane L; Reho, John J; Rahmouni, Kamal; Stauss, Harald M

Chapleau, Mark W; Rotella, Diane L; Reho, John J; Rahmouni, Kamal; Stauss, Harald M.

Affiliation

Chapleau MW; Department of Internal Medicine, University of Iowa, Iowa City, Iowa; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa; Veterans Affairs Medical Center, Iowa City, Iowa.
Rotella DL; Department of Health and Human Physiology, University of Iowa, Iowa City, Iowa;
Reho JJ; Department of Pharmacology, University of Iowa, Iowa City, Iowa; and.
Rahmouni K; Department of Pharmacology, University of Iowa, Iowa City, Iowa; and.
Stauss HM; Department of Health and Human Physiology, University of Iowa, Iowa City, Iowa; harald-stauss@uiowa.edu.

Am J Physiol Heart Circ Physiol ; 311(1): H276-85, 2016 07 01.

Article in En | MEDLINE | ID: mdl-27208157

Subject(s)

Aorta, Thoracic/physiopathology; Ciliary Arteries/physiopathology; Endothelium, Vascular/physiopathology; Hypertension/therapy; Sodium Chloride, Dietary; Stroke/prevention & control; Vagus Nerve Stimulation/methods; Vascular Stiffness; Vasodilation; Animals; Aorta, Thoracic/metabolism; Arterial Pressure; Ciliary Arteries/metabolism; Disease Models, Animal; Endothelium, Vascular/metabolism; Enzyme Activation; Heart Rate; Hypertension/blood; Hypertension/complications; Hypertension/physiopathology; Implantable Neurostimulators; Interleukin-6/blood; Male; Nitric Oxide/metabolism; Nitric Oxide Synthase Type III/metabolism; Phosphorylation; Rats, Inbred SHR; Severity of Illness Index; Stroke/etiology; Stroke/physiopathology; Time Factors; Vagus Nerve Stimulation/instrumentation

Key words

aortic distensibility; aortic pulse-wave velocity; cardiovascular end-organ damage; hypertension; nitric oxide-dependent relaxation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta, Thoracic / Vasodilation / Endothelium, Vascular / Sodium Chloride, Dietary / Ciliary Arteries / Stroke / Vagus Nerve Stimulation / Vascular Stiffness / Hypertension Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2016 Document type: Article Country of publication: United States

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