Therapeutic Administration of a Monoclonal Anti-Il-1ß Antibody Protects Against Experimental Melioidosis.

Weehuizen, Tassili A F; Lankelma, Jacqueline M; De Jong, Hanna K; De Boer, Onno J; Roelofs, Joris J T H; Day, Nicholas P; Gram, Hermann; De Vos, Alex F; Wiersinga, W Joost

Weehuizen, Tassili A F; Lankelma, Jacqueline M; De Jong, Hanna K; De Boer, Onno J; Roelofs, Joris J T H; Day, Nicholas P; Gram, Hermann; De Vos, Alex F; Wiersinga, W Joost.

Affiliation

Weehuizen TA; *Center for Infection and Immunity Amsterdam (CINIMA)/Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand §Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK ||Novartis Institute

Shock ; 46(5): 566-574, 2016 11.

Article in En | MEDLINE | ID: mdl-27219859

Subject(s)

Antibodies, Monoclonal/therapeutic use; Interleukin-1beta/antagonists & inhibitors; Melioidosis/drug therapy; Melioidosis/microbiology; Adolescent; Adult; Aged; Animals; Burkholderia pseudomallei/pathogenicity; Disease Models, Animal; Humans; Inflammasomes/drug effects; Inflammasomes/metabolism; Interleukin-1beta/metabolism; Middle Aged; NLR Family, Pyrin Domain-Containing 3 Protein/genetics; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; RNA, Messenger/genetics; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-1beta / Melioidosis / Antibodies, Monoclonal Limits: Adolescent / Adult / Aged / Animals / Humans / Middle aged Language: En Journal: Shock Journal subject: ANGIOLOGIA / CARDIOLOGIA Year: 2016 Document type: Article

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