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Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro.
Share, Andrew I; Patel, Khushali; Nativi, Cristina; Cho, Eun J; Francesconi, Oscar; Busschaert, Nathalie; Gale, Philip A; Roelens, Stefano; Sessler, Jonathan L.
Affiliation
  • Share AI; Department of Chemistry, The University of Texas, Austin, TX 78712-1224, USA. sessler@cm.utexas.edu.
Chem Commun (Camb) ; 52(48): 7560-3, 2016 Jun 18.
Article in En | MEDLINE | ID: mdl-27223254
ABSTRACT
A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl(-) transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus in vitro.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chlorides / Anion Transport Proteins / Methicillin-Resistant Staphylococcus aureus / Anti-Bacterial Agents Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2016 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chlorides / Anion Transport Proteins / Methicillin-Resistant Staphylococcus aureus / Anti-Bacterial Agents Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2016 Document type: Article Affiliation country: United States