Mobitz type I and II atrioventricular blocks during fingolimod therapy.
Neurol Sci
; 37(9): 1557-9, 2016 Sep.
Article
in En
| MEDLINE
| ID: mdl-27225279
ABSTRACT
We investigated patients who showed a second-degree atrioventricular block (S-AVB) after the first fingolimod administration. We observed six patients with S-AVB, three Mobitz type I, and three type II. Monitoring continued on the second day for all patients. Three patients showed persistence of the S-AVB, with resolution on the second or third day. One patient had a persistent S-AVB up to the fourth day when fingolimod was discontinued. We conclude that Mobitz type II S-AVB is possible during fingolimod therapy. Patients with S-AVB could be monitored until resolution of the S-AVBs, as these may persist several days after the first fingolimod administration.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Atrioventricular Block
/
Fingolimod Hydrochloride
/
Immunosuppressive Agents
/
Multiple Sclerosis
Type of study:
Diagnostic_studies
/
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Neurol Sci
Journal subject:
NEUROLOGIA
Year:
2016
Document type:
Article
Affiliation country:
Italy