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GMP-Grade mRNA Electroporation of Dendritic Cells for Clinical Use.
Derdelinckx, Judith; Berneman, Zwi N; Cools, Nathalie.
Affiliation
  • Derdelinckx J; Laboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp University Hospital (UZA), Wilrijkstraat 10, B-2650, Edegem, Belgium.
  • Berneman ZN; Laboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp University Hospital (UZA), Wilrijkstraat 10, B-2650, Edegem, Belgium.
  • Cools N; Laboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp University Hospital (UZA), Wilrijkstraat 10, B-2650, Edegem, Belgium. nathalie.cools@uza.be.
Methods Mol Biol ; 1428: 139-50, 2016.
Article in En | MEDLINE | ID: mdl-27236797
mRNA-electroporated dendritic cells (DC) are demonstrating clinical benefit in patients in many therapeutic areas, including cancer and infectious diseases. According to current good manufacturing guidelines, cell-based medicinal products have to be defined for identity, purity, potency, stability, and viability. In order to comply with the directives and guidelines defined by the regulatory authorities, we report here a standardized and reproducible method for the manufacturing of clinical-grade mRNA-transfected DC.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / RNA, Messenger / Electroporation Type of study: Guideline Limits: Humans Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2016 Document type: Article Affiliation country: Belgium Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / RNA, Messenger / Electroporation Type of study: Guideline Limits: Humans Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2016 Document type: Article Affiliation country: Belgium Country of publication: United States