Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation.

Aix, Esther; Gutiérrez-Gutiérrez, Óscar; Sánchez-Ferrer, Carlota; Aguado, Tania; Flores, Ignacio

Aix, Esther; Gutiérrez-Gutiérrez, Óscar; Sánchez-Ferrer, Carlota; Aguado, Tania; Flores, Ignacio.

Affiliation

Aix E; Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain.
Gutiérrez-Gutiérrez Ó; Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain.
Sánchez-Ferrer C; Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain.
Aguado T; Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain.
Flores I; Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain iflores@cnic.es.

J Cell Biol ; 213(5): 571-83, 2016 06 06.

Article in En | MEDLINE | ID: mdl-27241915

Subject(s)

Cell Cycle Checkpoints; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Myocytes, Cardiac/cytology; Myocytes, Cardiac/metabolism; Telomere/metabolism; Anaphase; Animals; Animals, Newborn; Cell Proliferation; DNA Damage; DNA Repair; Mice, Inbred C57BL; Models, Biological; Telomerase/metabolism; Telomere Homeostasis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Telomere / Myocytes, Cardiac / Cyclin-Dependent Kinase Inhibitor p21 / Cell Cycle Checkpoints Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Cell Biol Year: 2016 Document type: Article Affiliation country: Spain Country of publication: United States

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