1-(2-aminoethyl)-6-aryl-4H- [1,2,4]triazolo[4,3-a][1,4]benzodiazepines with diuretic and natriuretic activity.

Hester, J B; Ludens, J H; Emmert, D E; West, B E

Hester, J B; Ludens, J H; Emmert, D E; West, B E.

Affiliation

Hester JB; Cardiovascular Diseases Research, Upjohn Company, Kalamazoo, Michigan 49001.

J Med Chem ; 32(6): 1157-63, 1989 Jun.

Article in En | MEDLINE | ID: mdl-2724291

Subject(s)

Benzodiazepines/pharmacology; Diuresis/drug effects; Natriuresis/drug effects; Triazoles/pharmacology; Animals; Benzodiazepines/chemical synthesis; Chemical Phenomena; Chemistry; Chlorides/urine; Dogs; Dose-Response Relationship, Drug; Kidney/drug effects; Kidney/physiology; Male; Molecular Structure; Potassium/urine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Triazoles/chemical synthesis

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Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Benzodiazepines / Diuresis / Natriuresis Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1989 Document type: Article Country of publication: United States

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