The microscale evolution of the erosion front of blood clots exposed to ultrasound stimulated microbubbles.
J Acoust Soc Am
; 139(5): EL135, 2016 05.
Article
in En
| MEDLINE
| ID: mdl-27250198
ABSTRACT
Serial two-photon microscopy of blood clots with fluorescently tagged fibrin networks was conducted during microbubble-mediated sonothrombolysis to examine the microscale evolution of the resulting erosion front. The development of a complex zonal erosion pattern was observed, comprised of a cell depleted layer of fibrin network overlying intact clot which then underwent progressive recession. The fibrin zone architecture was dependent on exposure conditions with 0.1 MPa causing no erosion, 0.39 MPa resulting in homogenous structure, and combination 0.39/0.96 MPa pulses forming large-scale tunnels. High speed imaging and Coulter counter data indicated the fibrin zone formation process involves the ejection of intact erythrocytes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombosis
/
Ultrasonic Therapy
/
Fibrin
/
Microbubbles
/
Erythrocytes
/
Fibrinolysis
/
Mechanical Thrombolysis
Limits:
Humans
Language:
En
Journal:
J Acoust Soc Am
Year:
2016
Document type:
Article
Affiliation country:
Canada