Regulation of the Bioavailability of TGF-ß and TGF-ß-Related Proteins.
Cold Spring Harb Perspect Biol
; 8(6)2016 06 01.
Article
in En
| MEDLINE
| ID: mdl-27252363
ABSTRACT
The bioavailability of members of the transforming growth factor ß (TGF-ß) family is controlled by a number of mechanisms. Bona fide TGF-ß is sequestered into the matrix in a latent state and must be activated before it can bind to its receptors. Here, we review the molecules and mechanisms that regulate the bioavailability of TGF-ß and compare these mechanisms with those used to regulate other TGF-ß family members. We also assess the physiological significance of various latent TGF-ß activators, as well as other extracellular modulators of TGF-ß family signaling, by examining the available in vivo data from knockout mouse models and other biological systems.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biological Availability
/
Signal Transduction
/
Transforming Growth Factor beta
/
Latent TGF-beta Binding Proteins
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Cold Spring Harb Perspect Biol
Journal subject:
BIOLOGIA
Year:
2016
Document type:
Article