Aminoglycosides: An Overview.
Cold Spring Harb Perspect Med
; 6(6)2016 06 01.
Article
in En
| MEDLINE
| ID: mdl-27252397
ABSTRACT
Aminoglycosides are natural or semisynthetic antibiotics derived from actinomycetes. They were among the first antibiotics to be introduced for routine clinical use and several examples have been approved for use in humans. They found widespread use as first-line agents in the early days of antimicrobial chemotherapy, but were eventually replaced in the 1980s with cephalosporins, carbapenems, and fluoroquinolones. Aminoglycosides synergize with a variety of other antibacterial classes, which, in combination with the continued increase in the rise of multidrug-resistant bacteria and the potential to improve the safety and efficacy of the class through optimized dosing regimens, has led to a renewed interest in these broad-spectrum and rapidly bactericidal antibacterials.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aminoglycosides
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Cold Spring Harb Perspect Med
Year:
2016
Document type:
Article