Tumour Necrosis Factor-Alpha Gene Polymorphism (-308 G-A) in Turkish Pediatric Thrombosis Patients.
Turk J Haematol
; 19(1): 39-41, 2002 Mar 05.
Article
in En
| MEDLINE
| ID: mdl-27264624
ABSTRACT
Tumour necrosis factor-alpha (TNF-a) plays an important role in clot formation by activating platelets, monocytes and endothelial cells and inducing procoagulant substances such as negatively charged phospolipids or tissue factor. There is a genetically controlled inter-individual variation of TNF-a production. Carrying TNF2 allele could have a slight protective effect against the occurence of stroke in Sickle Cell Disease patients. We aimed to study this polymorphic site in Turkish children with the diagnosis of thrombosis.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Turk J Haematol
Year:
2002
Document type:
Article
Publication country:
TR
/
TURKEY
/
TURQUIA