Psychopharmacological Effects of Alkaloid Z77 under Conditions of Posthypoxic Encephalopathy and Mechanisms of Their Development.
Bull Exp Biol Med
; 161(1): 45-9, 2016 May.
Article
in En
| MEDLINE
| ID: mdl-27265139
ABSTRACT
Psychopharmacological effects of atisine-type diterpene alkaloid Z77 were studied under conditions of experimental posthypoxic encephalopathy. The preparation had a pronounced cerebroprotective effect consisting in normalization of orientation and exploratory behavior and conditioned activity in experimental animals. These changes were accompanied by significant increase in the number of neural stem cells in the paraventricular region of the brain and markedly enhanced production of neurotrophic growth factors by neural tissue microenvironment cells.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Diseases
/
Alkaloids
Limits:
Animals
Language:
En
Journal:
Bull Exp Biol Med
Year:
2016
Document type:
Article
Affiliation country:
RUSSIA