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Role of Progenitor Cells in Liver Regeneration after Subtotal Resection.
El'chaninov, A V; Fatkhudinov, T Kh; Kananykhina, E Yu; Usman, N Yu; Arutyunyan, I V; Makarov, A V; Bykov, A V; Bolshakova, G V; Sukhikh, G T.
Affiliation
  • El'chaninov AV; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Fatkhudinov TKh; Institute of Human Morphology, Moscow, Russia.
  • Kananykhina EY; N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Usman NY; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia. fatkhudinov@gmail.com.
  • Arutyunyan IV; Institute of Human Morphology, Moscow, Russia. fatkhudinov@gmail.com.
  • Makarov AV; N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia. fatkhudinov@gmail.com.
  • Bykov AV; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Bolshakova GV; Institute of Human Morphology, Moscow, Russia.
  • Sukhikh GT; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med ; 161(1): 155-61, 2016 May.
Article in En | MEDLINE | ID: mdl-27265142
ABSTRACT
In the liver of rats subjected to subtotal liver resection (80% organ weight), the expression of sox9 gene and SOX9 protein content increased and cells with hepatocyte morphology expressing SOX9 appeared; the proportion of cells expressing cytokeratin-19 also increased. Based on these data, we cannot completely exclude the involvement of resident progenitor cells and hepatocyte reprogramming in liver regeneration after subtotal resection, however, the contribution of these processes seems to be insignificant. The leading mechanism of liver mass recovery after subtotal resection is proliferation of hepatocytes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Hepatocytes / Liver / Liver Regeneration Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2016 Document type: Article Affiliation country: RUSSIA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Hepatocytes / Liver / Liver Regeneration Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2016 Document type: Article Affiliation country: RUSSIA