Transcriptional regulation of long-term potentiation.
Neurogenetics
; 17(4): 201-210, 2016 10.
Article
in En
| MEDLINE
| ID: mdl-27318935
ABSTRACT
Long-term potentiation (LTP), the persistent strengthening of synapses following high levels of stimulation, is a form of synaptic plasticity that has been studied extensively as a possible mechanism for learning and memory formation. The strengthening of the synapse that occurs during LTP requires cascades of complex molecular processes and the coordinated remodeling of pre-synaptic and post-synaptic neurons. Despite over four decades of research, our understanding of the transcriptional mechanisms and molecular processes underlying LTP remains incomplete. Identification of all the proteins and non-coding RNA transcripts expressed during LTP may provide greater insight into the molecular mechanisms involved in learning and memory formation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression Regulation
/
Long-Term Potentiation
Limits:
Animals
/
Humans
Language:
En
Journal:
Neurogenetics
Journal subject:
GENETICA
/
NEUROLOGIA
Year:
2016
Document type:
Article
Affiliation country:
Australia