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Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.
Galanos, Panagiotis; Vougas, Konstantinos; Walter, David; Polyzos, Alexander; Maya-Mendoza, Apolinar; Haagensen, Emma J; Kokkalis, Antonis; Roumelioti, Fani-Marlen; Gagos, Sarantis; Tzetis, Maria; Canovas, Begoña; Igea, Ana; Ahuja, Akshay K; Zellweger, Ralph; Havaki, Sofia; Kanavakis, Emanuel; Kletsas, Dimitris; Roninson, Igor B; Garbis, Spiros D; Lopes, Massimo; Nebreda, Angel; Thanos, Dimitris; Blow, J Julian; Townsend, Paul; Sørensen, Claus Storgaard; Bartek, Jiri; Gorgoulis, Vassilis G.
Affiliation
  • Galanos P; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, 75 Mikras Asias Str, Athens GR-11527, Greece.
  • Vougas K; Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou St., Athens GR-11527, Greece.
  • Walter D; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaloes Vej 5, Copenhagen DK-2200, Denmark.
  • Polyzos A; Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou St., Athens GR-11527, Greece.
  • Maya-Mendoza A; Genome Integrity Unit, Danish Cancer Society Research Centre, Strandboulevarden 49, Copenhagen DK-2100, Denmark.
  • Haagensen EJ; Centre for Gene Regulation &Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Kokkalis A; Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou St., Athens GR-11527, Greece.
  • Roumelioti FM; Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou St., Athens GR-11527, Greece.
  • Gagos S; Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou St., Athens GR-11527, Greece.
  • Tzetis M; Department of Medical Genetics, Medical School, University of Athens, Thivon &Levadias Str., Athens GR-11527, Greece.
  • Canovas B; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
  • Igea A; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
  • Ahuja AK; Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, Zurich CH-8057, Switzerland.
  • Zellweger R; Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, Zurich CH-8057, Switzerland.
  • Havaki S; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, 75 Mikras Asias Str, Athens GR-11527, Greece.
  • Kanavakis E; Department of Medical Genetics, Medical School, University of Athens, Thivon &Levadias Str., Athens GR-11527, Greece.
  • Kletsas D; Research Institute for the Study of Genetic and Malignant Disorders in Childhood, Aghia Sophia Children's Hospital, Thivon Str., Athens GR-11527, Greece.
  • Roninson IB; Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research 'Demokritos', Agia Paraskevi Attikis, PO Box 60228, Athens GR-153 10, Greece.
  • Garbis SD; Center for Targeted Therapeutics, Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Coker Life Science Building, 715 Sumter Street, Columbia, South Carolina 29208, USA.
  • Lopes M; Cancer and Clinical Experimental Science Units, Faculty of Medicine, Institute for Life Sciences, Center for Proteome Research, University of Southampton, University Road Southampton, Southampton SO17 1BJ, UK.
  • Nebreda A; Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, Zurich CH-8057, Switzerland.
  • Thanos D; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
  • Blow JJ; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain.
  • Townsend P; Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou St., Athens GR-11527, Greece.
  • Sørensen CS; Centre for Gene Regulation &Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Bartek J; Faculty Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Wilmslow Road, Manchester M20 4QL, UK.
  • Gorgoulis VG; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaloes Vej 5, Copenhagen DK-2200, Denmark.
Nat Cell Biol ; 18(7): 777-89, 2016 07.
Article in En | MEDLINE | ID: mdl-27323328
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genomic Instability / DNA Replication / Cyclin-Dependent Kinase Inhibitor p21 Type of study: Etiology_studies Limits: Humans Language: En Journal: Nat Cell Biol Year: 2016 Document type: Article Affiliation country: Greece
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genomic Instability / DNA Replication / Cyclin-Dependent Kinase Inhibitor p21 Type of study: Etiology_studies Limits: Humans Language: En Journal: Nat Cell Biol Year: 2016 Document type: Article Affiliation country: Greece