Polymyxins: a new hope in combating Gram-negative superbugs?

Velkov, Tony; Roberts, Kade D; Thompson, Philip E; Li, Jian

Velkov, Tony; Roberts, Kade D; Thompson, Philip E; Li, Jian.

Affiliation

Velkov T; Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia.
Roberts KD; Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia.
Thompson PE; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia.
Li J; Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, 19 Innovation Walk, Clayton 3800, Victoria, Australia.

Future Med Chem ; 8(10): 1017-25, 2016 06.

Article in En | MEDLINE | ID: mdl-27328129

Subject(s)

Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/pharmacology; Drug Discovery; Gram-Negative Bacterial Infections/drug therapy; Polymyxins/chemistry; Polymyxins/pharmacology; Animals; Anti-Bacterial Agents/toxicity; Chemistry, Pharmaceutical; Drug Resistance, Multiple, Bacterial; Humans; Polymyxins/toxicity

Key words

drug discovery; nephrotoxicity; polymyxins; resistance

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gram-Negative Bacterial Infections / Polymyxins / Drug Discovery / Anti-Bacterial Agents Limits: Animals / Humans Language: En Journal: Future Med Chem Year: 2016 Document type: Article Affiliation country: Australia Country of publication: United kingdom

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