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Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome.
Hsiao, J; Yuan, T Y; Tsai, M S; Lu, C Y; Lin, Y C; Lee, M L; Lin, S W; Chang, F C; Liu Pimentel, H; Olive, C; Coito, C; Shen, G; Young, M; Thorne, T; Lawrence, M; Magistri, M; Faghihi, M A; Khorkova, O; Wahlestedt, C.
Affiliation
  • Hsiao J; OPKO Health Inc., 10320 USA Today Way, Miramar, FL 33025, USA.
  • Yuan TY; OPKO Health Inc., 10320 USA Today Way, Miramar, FL 33025, USA.
  • Tsai MS; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Rd., Taipei 100, Taiwan.
  • Lu CY; Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan.
  • Lin YC; OPKO Health Inc., 10320 USA Today Way, Miramar, FL 33025, USA.
  • Lee ML; Dep. Clinical Laboratory Science and Medical Biotechnology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
  • Lin SW; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Rd., Taipei 100, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, Nati
  • Chang FC; Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan; Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Rd., Taipei 100, Taiwan; Graduate Ins
  • Liu Pimentel H; OPKO Health Inc., 10320 USA Today Way, Miramar, FL 33025, USA.
  • Olive C; OPKO Health Inc., 10320 USA Today Way, Miramar, FL 33025, USA.
  • Coito C; OPKO Health Inc., 10320 USA Today Way, Miramar, FL 33025, USA.
  • Shen G; OPKO Health Inc., 10320 USA Today Way, Miramar, FL 33025, USA.
  • Young M; OPKO Health Inc., 10320 USA Today Way, Miramar, FL 33025, USA.
  • Thorne T; OPKO Health Inc., 10320 USA Today Way, Miramar, FL 33025, USA.
  • Lawrence M; RxGen, 100 Deepwood Drive, Hamden, CT 06517, USA.
  • Magistri M; Center for Therapeutic Innovation and the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami 33136, FL, USA.
  • Faghihi MA; Center for Therapeutic Innovation and the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami 33136, FL, USA.
  • Khorkova O; OPKO Health Inc., 10320 USA Today Way, Miramar, FL 33025, USA.
  • Wahlestedt C; Center for Therapeutic Innovation and the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami 33136, FL, USA. Electronic address: CWahlestedt@med.miami.edu.
EBioMedicine ; 9: 257-277, 2016 Jul.
Article in En | MEDLINE | ID: mdl-27333023

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Epilepsies, Myoclonic / NAV1.1 Voltage-Gated Sodium Channel / RNA, Long Noncoding Language: En Journal: EBioMedicine Year: 2016 Document type: Article Affiliation country: United States Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Epilepsies, Myoclonic / NAV1.1 Voltage-Gated Sodium Channel / RNA, Long Noncoding Language: En Journal: EBioMedicine Year: 2016 Document type: Article Affiliation country: United States Country of publication: Netherlands