Effect of mid-luteal phase GnRH agonist on frozen-thawed embryo transfers during natural menstrual cycles: a randomised clinical pilot study.
Gynecol Endocrinol
; 32(12): 961-964, 2016 Dec.
Article
in En
| MEDLINE
| ID: mdl-27348542
ABSTRACT
This prospective randomised crossover study evaluated the effect of mid-luteal single-dose gonadotropin-releasing hormone agonist (triptoreline) on pregnancy outcomes in natural-cycle frozen embryo transfers (FETs). Ninety-eight women were randomised to receive either standard luteal support with vaginal micronised progesterone or an additional single dose of 0.1 mg triptoreline at the time of implantation. The intervention group was composed of 65 FET cycles and the control group of 62 cycles. In the intervention group, there were more positive pregnancy tests, clinical pregnancies and live births, but the differences did not reach statistical significance. The mean beta human chorionic gonadotropin (ß-hCG) concentration of singleton pregnancies was significantly lower in the intervention group compared to the control group (p = 0.048). No difference was detected in the median birth weight of the newborns.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Progesterone
/
Pregnancy Outcome
/
Gonadotropin-Releasing Hormone
/
Outcome Assessment, Health Care
/
Triptorelin Pamoate
/
Embryo Transfer
/
Luteolytic Agents
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Gynecol Endocrinol
Journal subject:
ENDOCRINOLOGIA
/
GINECOLOGIA
Year:
2016
Document type:
Article
Affiliation country:
Finland