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Development and Statistical Optimisation of Buspirone Hydrochloride Buccoadhesive Films.
Nagaich, Upendra; Chaudhary, Vandana; Nagaich, Jaya.
Affiliation
  • Nagaich U; Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh 201313, India.
  • Chaudhary V; Department of Pharmaceutics, B. S. Anangpuria Institute of Pharmacy, Faridabad, India.
  • Nagaich J; Department of Pharmaceutics, Kota College of Pharmacy, Kota, India.
Int Sch Res Notices ; 2014: 214026, 2014.
Article in En | MEDLINE | ID: mdl-27351002
The aim of the present study was to prepare unidirectional buccal films of buspirone hydrochloride by solvent casting technique. Hydroxypropylmethylcellulose (HPMC K15M) and Eudragit RL-100 were used as polymers in different proportion. Polyethylene glycol 400 and sodium lauryl sulphate were used as plasticizer and permeation enhancer, respectively, in different concentration. In the formulation, total amount of polymer (X 1) and percentage of HPMC K15M (X 2) were kept as independent variables. Afterwards, statistically optimized process was carried out and two optimized formulations (OF1 and OF2) were developed. The observed results of optimized formulation were showed a greater degree of percentage of similarity with predicted values. The stability studies showed that there was no significant change found in physicochemical properties, in-vitro release, and ex-vivo diffusion studies.

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Int Sch Res Notices Year: 2014 Document type: Article Affiliation country: India Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Int Sch Res Notices Year: 2014 Document type: Article Affiliation country: India Country of publication: United States