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Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response.
Gill, Kheshwant S; Fernandes, Philana; O'Donovan, Tracey R; McKenna, Sharon L; Doddakula, Kishore K; Power, Derek G; Soden, Declan M; Forde, Patrick F.
Affiliation
  • Gill KS; Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland; Cardiothoracic Surgery Department, Cork University Hospital, Cork, Ireland.
  • Fernandes P; Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland.
  • O'Donovan TR; Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland.
  • McKenna SL; Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland.
  • Doddakula KK; Cardiothoracic Surgery Department, Cork University Hospital, Cork, Ireland.
  • Power DG; Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland; Department of Medical Oncology, Mercy University Hospital, Grenville Place, Cork, Ireland.
  • Soden DM; Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland.
  • Forde PF; Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland. Electronic address: p.forde@ucc.ie.
Biochim Biophys Acta ; 1866(1): 87-105, 2016 08.
Article in En | MEDLINE | ID: mdl-27373814
ABSTRACT
Increased glycolysis is the main source of energy supply in cancer cells that use this metabolic pathway for ATP generation. Altered energy metabolism is a biochemical fingerprint of cancer cells that represents one of the "hallmarks of cancer". The immune system can prevent tumour growth by eliminating cancer cells but this editing process ultimately results in poorly immunogenic cells remaining allowing for unchallenged tumour growth. In this review we look at the glycolysis pathway as a target for cancer treatments. We also examine the interplay between the glycolysis modulation and the immune response as an anti-cancer therapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycolysis / Immunity, Cellular / Neoplasms Limits: Humans Language: En Journal: Biochim Biophys Acta Year: 2016 Document type: Article Affiliation country: Ireland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycolysis / Immunity, Cellular / Neoplasms Limits: Humans Language: En Journal: Biochim Biophys Acta Year: 2016 Document type: Article Affiliation country: Ireland