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Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress.
Doshi, Kshama A; Trotta, Rossana; Natarajan, Karthika; Rassool, Feyruz V; Tron, Adriana E; Huszar, Dennis; Perrotti, Danilo; Baer, Maria R.
Affiliation
  • Doshi KA; University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Trotta R; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Natarajan K; University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Rassool FV; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Tron AE; University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Huszar D; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Perrotti D; University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Baer MR; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.
Oncotarget ; 7(30): 48280-48295, 2016 Jul 26.
Article in En | MEDLINE | ID: mdl-27374090
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Leukemia, Myeloid, Acute / Oxidative Stress / Proto-Oncogene Proteins c-pim-1 / Fms-Like Tyrosine Kinase 3 / Topoisomerase II Inhibitors Limits: Humans Language: En Journal: Oncotarget Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Leukemia, Myeloid, Acute / Oxidative Stress / Proto-Oncogene Proteins c-pim-1 / Fms-Like Tyrosine Kinase 3 / Topoisomerase II Inhibitors Limits: Humans Language: En Journal: Oncotarget Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States