Upregulation of MicroRNA-214 Contributes to the Development of Vascular Remodeling in Hypoxia-induced Pulmonary Hypertension Via Targeting CCNL2.

Liu, HaiTao; Tao, Yin; Chen, Mai; Yu, Jin; Li, Wei-Jie; Tao, Ling; Li, Yan; Li, Fei

Liu, HaiTao; Tao, Yin; Chen, Mai; Yu, Jin; Li, Wei-Jie; Tao, Ling; Li, Yan; Li, Fei.

Affiliation

Liu H; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Tao Y; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Chen M; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yu J; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Li WJ; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Tao L; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Li Y; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Li F; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Sci Rep ; 6: 24661, 2016 07 06.

Article in En | MEDLINE | ID: mdl-27381447

Subject(s)

Cell Hypoxia; Cyclins/metabolism; Hypertension, Pulmonary/diagnosis; MicroRNAs/metabolism; Pulmonary Disease, Chronic Obstructive/diagnosis; Transcription Factors/metabolism; Vascular Remodeling/physiology; Aged; Animals; Base Sequence; Case-Control Studies; Cells, Cultured; Cyclins/antagonists & inhibitors; Cyclins/genetics; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary/complications; Hypertension, Pulmonary/genetics; Male; Mice; Mice, Inbred C57BL; MicroRNAs/antagonists & inhibitors; MicroRNAs/genetics; Middle Aged; Myocytes, Smooth Muscle/cytology; Myocytes, Smooth Muscle/metabolism; Pulmonary Artery/cytology; Pulmonary Disease, Chronic Obstructive/complications; Transcription Factors/antagonists & inhibitors; Transcription Factors/genetics; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Cell Hypoxia / Cyclins / Pulmonary Disease, Chronic Obstructive / MicroRNAs / Vascular Remodeling / Hypertension, Pulmonary Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Sci Rep Year: 2016 Document type: Article Affiliation country: China Country of publication: United kingdom

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