Your browser doesn't support javascript.
loading
Phototactic guidance of a tissue-engineered soft-robotic ray.
Park, Sung-Jin; Gazzola, Mattia; Park, Kyung Soo; Park, Shirley; Di Santo, Valentina; Blevins, Erin L; Lind, Johan U; Campbell, Patrick H; Dauth, Stephanie; Capulli, Andrew K; Pasqualini, Francesco S; Ahn, Seungkuk; Cho, Alexander; Yuan, Hongyan; Maoz, Ben M; Vijaykumar, Ragu; Choi, Jeong-Woo; Deisseroth, Karl; Lauder, George V; Mahadevan, L; Parker, Kevin Kit.
Affiliation
  • Park SJ; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Gazzola M; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Park KS; Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 121-742, Korea. Sogang-Harvard Research Center for Disease Biophysics, Sogang University, Seoul 121-742, Korea.
  • Park S; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Di Santo V; Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA.
  • Blevins EL; Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA.
  • Lind JU; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Campbell PH; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Dauth S; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Capulli AK; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Pasqualini FS; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Ahn S; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Cho A; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Yuan H; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Maoz BM; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Vijaykumar R; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Choi JW; Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 121-742, Korea. Sogang-Harvard Research Center for Disease Biophysics, Sogang University, Seoul 121-742, Korea.
  • Deisseroth K; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA. Department of Psychiatry and Behavioral Sciences and the Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
  • Lauder GV; Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA.
  • Mahadevan L; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. Department of Organismic and Evolutionary Biology, Department of Physics, Wyss Institute for Biologically Inspired Engineering, Kavli Institute for Nanobio Science and Technology, Harvard Univer
  • Parker KK; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. Sogang-Harvard Research Center for Disease Biophysics, Sogang University, Seoul 121-742, Korea. kkparker@seas.harv
Science ; 353(6295): 158-62, 2016 Jul 08.
Article in En | MEDLINE | ID: mdl-27387948
Inspired by the relatively simple morphological blueprint provided by batoid fish such as stingrays and skates, we created a biohybrid system that enables an artificial animal--a tissue-engineered ray--to swim and phototactically follow a light cue. By patterning dissociated rat cardiomyocytes on an elastomeric body enclosing a microfabricated gold skeleton, we replicated fish morphology at 1/10 scale and captured basic fin deflection patterns of batoid fish. Optogenetics allows for phototactic guidance, steering, and turning maneuvers. Optical stimulation induced sequential muscle activation via serpentine-patterned muscle circuits, leading to coordinated undulatory swimming. The speed and direction of the ray was controlled by modulating light frequency and by independently eliciting right and left fins, allowing the biohybrid machine to maneuver through an obstacle course.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Swimming / Robotics / Skates, Fish / Tissue Engineering / Light Type of study: Guideline Limits: Animals Language: En Journal: Science Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Swimming / Robotics / Skates, Fish / Tissue Engineering / Light Type of study: Guideline Limits: Animals Language: En Journal: Science Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States