Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity.
J Nat Prod
; 79(7): 1872-6, 2016 07 22.
Article
in En
| MEDLINE
| ID: mdl-27399938
ABSTRACT
Antibacterial-guided fractionation of the Dictyoceratid sponges Lamellodysidea sp. and two samples of Dysidea granulosa yielded 14 polybrominated, diphenyl ethers including one new methoxy-containing compound (8). Their structures were elucidated by interpretation of spectroscopic data of the natural product and their methoxy derivatives. Most of the compounds showed strong antimicrobial activity with low- to sub-microgram mL(-1) minimum inhibitory concentrations against drug-susceptible and drug-resistant strains of Staphylococcus aureus and Enterococcus faecium, and two compounds inhibited Escherichia coli in a structure-dependent manner.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dysidea
/
Halogenated Diphenyl Ethers
/
Anti-Bacterial Agents
Limits:
Animals
Language:
En
Journal:
J Nat Prod
Year:
2016
Document type:
Article
Affiliation country:
United States