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Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity.
Liu, Hongbing; Lohith, Katheryn; Rosario, Margaret; Pulliam, Thomas H; O'Connor, Robert D; Bell, Lori J; Bewley, Carole A.
Affiliation
  • Liu H; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892-0820, United States.
  • Lohith K; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892-0820, United States.
  • Rosario M; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892-0820, United States.
  • Pulliam TH; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892-0820, United States.
  • O'Connor RD; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892-0820, United States.
  • Bell LJ; Coral Reef Research Foundation , Koror, PW 96940, Palau.
  • Bewley CA; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892-0820, United States.
J Nat Prod ; 79(7): 1872-6, 2016 07 22.
Article in En | MEDLINE | ID: mdl-27399938
ABSTRACT
Antibacterial-guided fractionation of the Dictyoceratid sponges Lamellodysidea sp. and two samples of Dysidea granulosa yielded 14 polybrominated, diphenyl ethers including one new methoxy-containing compound (8). Their structures were elucidated by interpretation of spectroscopic data of the natural product and their methoxy derivatives. Most of the compounds showed strong antimicrobial activity with low- to sub-microgram mL(-1) minimum inhibitory concentrations against drug-susceptible and drug-resistant strains of Staphylococcus aureus and Enterococcus faecium, and two compounds inhibited Escherichia coli in a structure-dependent manner.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dysidea / Halogenated Diphenyl Ethers / Anti-Bacterial Agents Limits: Animals Language: En Journal: J Nat Prod Year: 2016 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dysidea / Halogenated Diphenyl Ethers / Anti-Bacterial Agents Limits: Animals Language: En Journal: J Nat Prod Year: 2016 Document type: Article Affiliation country: United States