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Tropheryma whipplei associated with diarrhoea in young children.
Fenollar, F; Minodier, P; Boutin, A; Laporte, R; Brémond, V; Noël, G; Miramont, S; Richet, H; Benkouiten, S; Lagier, J-C; Gaudart, J; Jouve, J-L; Raoult, D.
Affiliation
  • Fenollar F; Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM63, CRNS7278, IRD198, InsermU1095, Institut Hospitalo-Universitaire Méditerranée-Infection, Aix-Marseille Université, Marseille, France.
  • Minodier P; Paediatric Emergency Unit, Hôpital Nord, Marseille, France.
  • Boutin A; Paediatric Emergency Unit, Hôpital Timone, Marseille, France.
  • Laporte R; Paediatric Emergency Unit, Hôpital Nord, Marseille, France.
  • Brémond V; Paediatric Emergency Unit, Hôpital Timone, Marseille, France.
  • Noël G; Paediatric Emergency Unit, Hôpital Nord, Marseille, France.
  • Miramont S; Paediatric Emergency Unit, Hôpital Timone, Marseille, France.
  • Richet H; Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM63, CRNS7278, IRD198, InsermU1095, Institut Hospitalo-Universitaire Méditerranée-Infection, Aix-Marseille Université, Marseille, France.
  • Benkouiten S; Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM63, CRNS7278, IRD198, InsermU1095, Institut Hospitalo-Universitaire Méditerranée-Infection, Aix-Marseille Université, Marseille, France.
  • Lagier JC; Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM63, CRNS7278, IRD198, InsermU1095, Institut Hospitalo-Universitaire Méditerranée-Infection, Aix-Marseille Université, Marseille, France.
  • Gaudart J; Aix-Marseille University, UMR912 SESSTIM (INSERM-IRD-AMU), Marseille, France.
  • Jouve JL; Paediatric Emergency Unit, Hôpital Timone, Marseille, France.
  • Raoult D; Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM63, CRNS7278, IRD198, InsermU1095, Institut Hospitalo-Universitaire Méditerranée-Infection, Aix-Marseille Université, Marseille, France. Electronic address: didier.raoult@gmail.com.
Clin Microbiol Infect ; 22(10): 869-874, 2016 Oct.
Article in En | MEDLINE | ID: mdl-27404363
Tropheryma whipplei was detected in preliminary studies in faeces of young children with diarrhoea and also in faeces of asymptomatic persons, not only in Europe but also in Africa. In this study, the link between this bacterium and the presence of acute diarrhoea was evaluated in a large group of children. From December 2009 to January 2013, rectal swabs collected from 3796 children in the emergency departments of university hospitals in Marseille, France, were analysed: 555 children (245 female and 310 male, from 6 days to 6 years old) with acute diarrhoea defined as at least three loose stools per day for <1 week and 3241 children (1444 female and 1797 male, from 22 days to 6 years old) without diarrhoea. Specific quantitative real-time PCR was performed to detect the presence of T. whipplei and of two enteric pathogens Clostridium difficile and Giardia duodenalis. Tropheryma whipplei was significantly more common in children with diarrhoea (22/555, 4%) than without (56/3241, 1.7%; p 0.001). Neither C. difficile nor G. duodenalis showed this association. For C. difficile, 39 of 531 (7.3%) children with diarrhoea were positive versus 184 of 3119 (5.9%) of children without diarrhoea (p 0.25). For G. duodenalis, 2 of 529 (0.37%) children with diarrhoea were positive versus 5 of 3119 (0.16%) children without diarrhoea (p 0.26). Tropheryma whipplei was found more commonly in autumn. Tropheryma whipplei is significantly associated with diarrhoea in children, suggesting that the bacterium may be a cause of acute diarrhoea.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diarrhea / Tropheryma / Whipple Disease Type of study: Risk_factors_studies Limits: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Country/Region as subject: Europa Language: En Journal: Clin Microbiol Infect Journal subject: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Year: 2016 Document type: Article Affiliation country: France Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diarrhea / Tropheryma / Whipple Disease Type of study: Risk_factors_studies Limits: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Country/Region as subject: Europa Language: En Journal: Clin Microbiol Infect Journal subject: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Year: 2016 Document type: Article Affiliation country: France Country of publication: United kingdom