Thiol-Disulfide Exchange in Gram-Positive Firmicutes.
Trends Microbiol
; 24(11): 902-915, 2016 11.
Article
in En
| MEDLINE
| ID: mdl-27426970
ABSTRACT
Extracytoplasmic thiol-disulfide oxidoreductases (TDORs) catalyze the oxidation, reduction, and isomerization of protein disulfide bonds. Although these processes have been characterized in Gram-negative bacteria, the majority of Gram-positive TDORs have only recently been discovered. Results from recent studies have revealed distinct trends in the types of TDOR used by different groups of Gram-positive bacteria, and in their biological functions. Actinobacteria TDORs can be essential for viability, while Firmicute TDORs influence various physiological processes, including protein stability, oxidative stress resistance, bacteriocin production, and virulence. In this review we discuss the diverse extracytoplasmic TDORs used by Gram-positive bacteria, with a focus on Gram-positive Firmicutes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Disulfide Reductase (Glutathione)
/
Firmicutes
Language:
En
Journal:
Trends Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2016
Document type:
Article