Administration of probiotic mixture DM#1 ameliorated 5-fluorouracil-induced intestinal mucositis and dysbiosis in rats.

Tang, Yan; Wu, Yingtao; Huang, Ziyi; Dong, Weiwei; Deng, Ying; Wang, Fengjiao; Li, Ming; Yuan, Jieli

Tang, Yan; Wu, Yingtao; Huang, Ziyi; Dong, Weiwei; Deng, Ying; Wang, Fengjiao; Li, Ming; Yuan, Jieli.

Affiliation

Tang Y; Department of Microecology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Wu Y; Department of Microecology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Huang Z; Department of Microecology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Dong W; Department of Microecology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Deng Y; Department of Microecology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Wang F; Department of Microecology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Li M; Department of Microecology, College of Basic Medical Science, Dalian Medical University, Dalian, China. Electronic address: Vivianmarat@163.com.
Yuan J; Department of Microecology, College of Basic Medical Science, Dalian Medical University, Dalian, China. Electronic address: zgwst@126.com.

Nutrition ; 33: 96-104, 2017 Jan.

Article in En | MEDLINE | ID: mdl-27427511

Subject(s)

Cytokines/metabolism; Dysbiosis/drug therapy; Gastrointestinal Microbiome/drug effects; Ileum/drug effects; Intestinal Mucosa/drug effects; Mucositis/drug therapy; Probiotics/therapeutic use; Animals; Fluorouracil; Ileum/metabolism; Ileum/pathology; Inflammation/metabolism; Interleukin-4/metabolism; Interleukin-6/metabolism; Intestinal Mucosa/metabolism; Intestinal Mucosa/pathology; Male; Mucositis/chemically induced; Mucositis/metabolism; Neutrophil Infiltration; Permeability; RNA, Messenger/metabolism; Random Allocation; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 2/genetics; Toll-Like Receptor 2/metabolism; Toll-Like Receptor 4/genetics; Toll-Like Receptor 4/metabolism; Toll-Like Receptors; Tumor Necrosis Factor-alpha/metabolism

Key words

5-fluorouracil; Intestinal dysbiosis; Intestinal mucositis; Probiotics; Toll-like receptors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / Probiotics / Mucositis / Dysbiosis / Gastrointestinal Microbiome / Ileum / Intestinal Mucosa Limits: Animals Language: En Journal: Nutrition Journal subject: CIENCIAS DA NUTRICAO Year: 2017 Document type: Article Affiliation country: China

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