Recent advances in targeting the telomeric G-quadruplex DNA sequence with small molecules as a strategy for anticancer therapies.

Islam, Mohammad K; Jackson, Paul Jm; Rahman, Khondaker M; Thurston, David E

Islam, Mohammad K; Jackson, Paul Jm; Rahman, Khondaker M; Thurston, David E.

Affiliation

Islam MK; Institute of Pharmaceutical Science, Britannia House, King's College London, London SE1 1DB, UK.
Jackson PJ; Institute of Pharmaceutical Science, Britannia House, King's College London, London SE1 1DB, UK.
Rahman KM; Institute of Pharmaceutical Science, Britannia House, King's College London, London SE1 1DB, UK.
Thurston DE; Institute of Pharmaceutical Science, Britannia House, King's College London, London SE1 1DB, UK.

Future Med Chem ; 8(11): 1259-90, 2016 07.

Article in En | MEDLINE | ID: mdl-27442231

Subject(s)

Antineoplastic Agents/pharmacology; G-Quadruplexes/drug effects; Neoplasms/drug therapy; Small Molecule Libraries/pharmacology; Telomere/drug effects; Telomere/genetics; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/chemistry; Base Sequence; Humans; Nucleic Acid Conformation; Small Molecule Libraries/chemical synthesis; Small Molecule Libraries/chemistry

Key words

DNA G-quadruplex; DNA/small-molecule interaction; G-quadruplex targeting; anticancer agent; antitumor agent; drug discovery; human telomeres; molecular modeling; rational drug design; telomerase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Telomere / Small Molecule Libraries / G-Quadruplexes / Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Future Med Chem Year: 2016 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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