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Suicide in the Early Stage of Schizophrenia.
Ventriglio, Antonio; Gentile, Alessandro; Bonfitto, Iris; Stella, Eleonora; Mari, Massimo; Steardo, Luca; Bellomo, Antonello.
Affiliation
  • Ventriglio A; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; Department of Mental Health, Regione Marche, ASUR, Area Vasta 2, Jesi, Italy.
  • Gentile A; Department of Mental Health, Regione Veneto, ULSS 13 , Mirano , Italy.
  • Bonfitto I; Department of Clinical and Experimental Medicine, University of Foggia , Foggia , Italy.
  • Stella E; Department of Clinical and Experimental Medicine, University of Foggia , Foggia , Italy.
  • Mari M; Department of Mental Health, Regione Marche, ASUR, Area Vasta 2 , Jesi , Italy.
  • Steardo L; Department of Psychiatry, University of Naples SUN , Naples , Italy.
  • Bellomo A; Department of Clinical and Experimental Medicine, University of Foggia , Foggia , Italy.
Front Psychiatry ; 7: 116, 2016.
Article in En | MEDLINE | ID: mdl-27445872
ABSTRACT
Suicide is a relevant leading cause of death among patients affected by schizophrenia. Even if suicidal ideation may be present in different stages of disease, some differences have been described between the risk of suicide in patients experiencing first episode of psychosis and those with long-term schizophrenia. It is particularly higher during the first year of illness and reaches a steady decline over the following years. Suicidal ideation and attempts may also be common among subjects with subthreshold psychotic experiences. Factors associated with the risk of suicide in the early phase of schizophrenia are previous suicidal attempts and social aspects the lack of social support and stable relationships, social drift after the first episode, and social impairment. Also, several psychotic symptoms (suspiciousness, paranoid delusions, mental disintegration and agitation, negative symptoms, depression and hopelessness, and command hallucinations) and substance abuse are associated with higher risk of suicide. It has been described that perfectionism and good levels of insight among individuals who have recently developed psychotic symptoms are significantly associated with higher numbers of suicidal attempts. Moreover, recent evidences show that prefrontal cortex-based circuit dysfunction may be related to suicide in the early stage of schizophrenia. This narrative review summarizes available evidences on suicide in the early stage of schizophrenia and deals with issues to be further studied and discussed.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Front Psychiatry Year: 2016 Document type: Article Affiliation country: Italy

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Front Psychiatry Year: 2016 Document type: Article Affiliation country: Italy