Glucose-dependent insulinotropic polypeptide (GIP) dose-dependently reduces osteoclast differentiation and resorption.

Mabilleau, Guillaume; Perrot, Rodolphe; Mieczkowska, Aleksandra; Boni, Sébastien; Flatt, Peter R; Irwin, Nigel; Chappard, Daniel

Mabilleau, Guillaume; Perrot, Rodolphe; Mieczkowska, Aleksandra; Boni, Sébastien; Flatt, Peter R; Irwin, Nigel; Chappard, Daniel.

Affiliation

Mabilleau G; GEROM Groupe Etudes Remodelage Osseux et bioMatériaux - LHEA, IRIS-IBS Institut de Biologie en Santé, University of Angers, 49933 ANGERS Cedex, France; SCIAM, Service Commun d'Imagerie et Analyses Microscopiques, IRIS-IBS Institut de Biologie en Santé, University of Angers, 49933 ANGERS Cedex, Franc
Perrot R; SCIAM, Service Commun d'Imagerie et Analyses Microscopiques, IRIS-IBS Institut de Biologie en Santé, University of Angers, 49933 ANGERS Cedex, France.
Mieczkowska A; GEROM Groupe Etudes Remodelage Osseux et bioMatériaux - LHEA, IRIS-IBS Institut de Biologie en Santé, University of Angers, 49933 ANGERS Cedex, France.
Boni S; Lentivec, IRIS-IBS Institut de Biologie en Santé, University of Angers, 49933 ANGERS Cedex, France.
Flatt PR; SAAD Centre for Pharmacy and Diabetes, Diabetes Research Group, Biomedical Sciences Research Institute, University of Ulster, BT52 1SA Coleraine, United Kingdom.
Irwin N; SAAD Centre for Pharmacy and Diabetes, Diabetes Research Group, Biomedical Sciences Research Institute, University of Ulster, BT52 1SA Coleraine, United Kingdom.
Chappard D; GEROM Groupe Etudes Remodelage Osseux et bioMatériaux - LHEA, IRIS-IBS Institut de Biologie en Santé, University of Angers, 49933 ANGERS Cedex, France; SCIAM, Service Commun d'Imagerie et Analyses Microscopiques, IRIS-IBS Institut de Biologie en Santé, University of Angers, 49933 ANGERS Cedex, Franc

Bone ; 91: 102-12, 2016 10.

Article in En | MEDLINE | ID: mdl-27451082

Subject(s)

Bone Resorption/drug therapy; Bone Resorption/pathology; Cell Differentiation/drug effects; Gastric Inhibitory Polypeptide/pharmacology; Gastric Inhibitory Polypeptide/therapeutic use; Osteoclasts/pathology; Adenylyl Cyclases/metabolism; Amino Acid Sequence; Animals; Calcium/metabolism; Cancellous Bone/diagnostic imaging; Cancellous Bone/drug effects; Cancellous Bone/pathology; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Cortical Bone/diagnostic imaging; Cortical Bone/drug effects; Cortical Bone/pathology; Cyclic AMP/metabolism; Cyclic AMP-Dependent Protein Kinases/metabolism; Gastric Inhibitory Polypeptide/chemistry; Humans; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/metabolism; Leukocytes, Mononuclear/pathology; Male; Mice; Mice, Inbred BALB C; Osteoclasts/drug effects; Peptide Hydrolases/metabolism; Protein Transport/drug effects; RAW 264.7 Cells; Signal Transduction/drug effects; X-Ray Microtomography

Key words

Bone resorption; N-AcGIP; Osteoclast; Osteoclastogenesis; [d-Ala(2)]-GIP

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Bone Resorption / Gastric Inhibitory Polypeptide / Cell Differentiation Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Bone Journal subject: METABOLISMO / ORTOPEDIA Year: 2016 Document type: Article

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