JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses.

Fu, Yu; Gaelings, Lana; Söderholm, Sandra; Belanov, Sergei; Nandania, Jatin; Nyman, Tuula A; Matikainen, Sampsa; Anders, Simon; Velagapudi, Vidya; Kainov, Denis E

Fu, Yu; Gaelings, Lana; Söderholm, Sandra; Belanov, Sergei; Nandania, Jatin; Nyman, Tuula A; Matikainen, Sampsa; Anders, Simon; Velagapudi, Vidya; Kainov, Denis E.

Affiliation

Fu Y; The Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.
Gaelings L; The Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.
Söderholm S; Institute of Biotechnology (BI), University of Helsinki, Finland; Finnish Institute of Occupational Health (TTL), Helsinki, Finland.
Belanov S; The Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.
Nandania J; The Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.
Nyman TA; Institute of Biotechnology (BI), University of Helsinki, Finland.
Matikainen S; Finnish Institute of Occupational Health (TTL), Helsinki, Finland.
Anders S; The Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.
Velagapudi V; The Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.
Kainov DE; The Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland. Electronic address: denis.kainov@helsinki.fi.

Antiviral Res ; 133: 23-31, 2016 09.

Article in En | MEDLINE | ID: mdl-27451344

Subject(s)

Antiviral Agents/pharmacology; Host-Pathogen Interactions/drug effects; Influenza A virus/drug effects; Influenza A virus/physiology; Virus Replication/drug effects; Antiviral Agents/chemistry; Binding Sites; Cluster Analysis; Cytokines/genetics; Cytokines/metabolism; Dose-Response Relationship, Drug; Gene Expression Profiling; Host-Pathogen Interactions/genetics; Humans; Influenza, Human/genetics; Influenza, Human/metabolism; Influenza, Human/virology; Macrophages/drug effects; Macrophages/metabolism; Macrophages/virology; Metabolome; Metabolomics/methods; Models, Molecular; Molecular Conformation; Protein Binding; Protein Interaction Domains and Motifs; RNA-Dependent RNA Polymerase/chemistry; RNA-Dependent RNA Polymerase/metabolism; Viral Proteins/chemistry; Viral Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Influenza A virus / Virus Replication / Host-Pathogen Interactions Limits: Humans Language: En Journal: Antiviral Res Year: 2016 Document type: Article Affiliation country: Finland

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